Article
Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2008
Kim Hongsung, Peng Guangyong, Hicks John M, Weiss Heidi L, Van Meir Erwin G, Brenner Malcolm K, Yotnda Patricia
Abstract excerpt
Hypoxia occurs in many tumors and reduces the effectiveness of radio- and chemotherapy. Hypoxia also impedes immune responses to tumors, reducing T lymphocyte production of cytokines such as interleukin-2 (IL-2) and interferon gamma, as well as the survival and proliferation of these cells. We constructed a lentiviral vector encoding a bidirectional hypoxia-inducible responsive element (HRE) derived from human...
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