Article
The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype.
Oncogene - 20 Jul 2000
Nguyen M, Lee M C, Wang J L, Tomlinson J S, Shao Z M, Alpaugh M L, Barsky S H
Abstract excerpt
Human myoepithelial cells which surround ducts and acini of certain organs such as the breast form a natural border separating epithelial cells from stromal angiogenesis. Myoepithelial cell lines (HMS-1-6), derived from diverse benign myoepithelial tumors, all constitutively express high levels of active angiogenic inhibitors which include TIMP-1, thrombospondin-1 and soluble bFGF receptors but very low levels of...
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