Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors.

doi:10.1158/0008-5472.CAN-10-0412

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Article

Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors.

Cancer research - 1 Aug 2010

Sasajima Junpei, Mizukami Yusuke, Sugiyama Yoshiaki, Nakamura Kazumasa, Kawamoto Toru, Koizumi Kazuya, Fujii Rie, Motomura Wataru, Sato Kazuya, Suzuki Yasuaki, Tanno Satoshi, Fujiya Mikihiro, Sasaki Katsunori, Shimizu Norihiko, Karasaki Hidenori, Kono Toru, Kawabe Jun-ichi, Ii Masaaki, Yoshiara Hiroki, Kamiyama Naohisa, Ashida Toshifumi, Bardeesy Nabeel, Chung Daniel C, Kohgo Yutaka

Abstract excerpt

Blood vessels deliver oxygen and nutrients to tissues, and vascular networks are spatially organized to meet the metabolic needs for maintaining homeostasis. In contrast, the vasculature of tumors is immature and leaky, resulting in insufficient delivery of nutrients and oxygen. Vasculogenic processes occur normally in adult tissues to repair "injured" blood vessels, leading us to hypothesize that bone marrow...

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PMID: 20631070
DOI: 10.1158/0008-5472.CAN-10-0412
PMCID: PMC3063898

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CXCR4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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