Article
Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms.
Genes and immunity - 1 Mar 2007
Thiel S, Steffensen R, Christensen I J, Ip W K, Lau Y L, Reason I J M, Eiberg H, Gadjeva M, Ruseva M, Jensenius J C
Abstract excerpt
Mannan-binding lectin (MBL) and ficolins distinguish between self, non-self and altered-self by recognizing patterns of ligands on the surface of microorganisms or aberrant cells. When this happens MBL-associated serine protease-2 (MASP-2) is activated and cleaves complement factors to start inflammatory actions. We examined human populations for MASP-2 levels, MASP-2 function and for the presence of mutations in...
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