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Article

Thymidylate synthetase allelic imbalance in clear cell renal carcinoma.

Cancer chemotherapy and pharmacology - 1 Nov 2009

Colavito Davide, Cartei Giuseppe, Dal Bianco Massimo, Stecca Anna, Zustovich Fable, Dalle Carbonare Maurizio, Ragazzi Eugenio, Farina Miriam, Colombrino Eva, Leon Alberta

Abstract excerpt

PURPOSE: To investigate the allelic status of the thymidylate synthetase (TYMS) gene, located at chromosome band 18p11.32, in renal cell carcinoma (RCC). TYMS is a key target of the 5-fluorouracil (5-FU)-based class of drugs, frequently considered in combination therapies in advanced RCC. TYMS variants, such as the TYMS polymorphic 5'-untranslated region variable number tandem repeat sequence (VNTR), are under...

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Identifiers

PMID: 19306093
DOI: 10.1007/s00280-009-0986-9

Genes

TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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