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Article

Delimiting Allelic Imbalance of TYMS by Allele-Specific Analysis.

Medicine - 1 Jul 2015

Balboa-Beltrán Emilia, Cruz Raquel, Carracedo Angel, Barros Francisco

Abstract excerpt

Allelic imbalance of thymidylate synthase (TYMS) is attributed to polymorphisms in the 5'- and 3'-untranslated region (UTR). These polymorphisms have been related to the risk of suffering different cancers, for example leukemia, breast or gastric cancer, and response to different drugs, among which are methotrexate glutamates, stavudine, and specifically 5-fluorouracil (5-FU), as TYMS is its direct target. A vast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26166093
DOI: 10.1097/MD.0000000000001091
PMCID: PMC4504634

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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