Article
Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.
International journal of cancer - 1 Jan 2016
Meulendijks Didier, Jacobs Bart A W, Aliev Abidin, Pluim Dick, van Werkhoven Erik, Deenen Maarten J, Beijnen Jos H, Cats Annemieke, Schellens Jan H M
Abstract excerpt
The fluoropyrimidines act by inhibiting thymidylate synthase (TS). Recent studies have shown that patients' risk of severe fluoropyrimidine-associated toxicity is affected by polymorphisms in the 5'-untranslated region of TYMS, the gene encoding TS. A G>C substitution in the promoter enhancer region of TYMS, rs183205964 (known as the 2RC allele), markedly reduces TS activity in vitro, but its clinical relevance...
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