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Article

Important roles of the conserved linker-KKS in human neuronal growth inhibitory factor.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Oct 2009

Ding Zhi-Chun, Teng Xin-Chen, Zheng Qi, Ni Feng-Yun, Cai Bin, Wang Yang, Zhou Guo-Ming, Sun Hong-Zhe, Tan Xiang-Shi, Huang Zhong-Xian

Abstract excerpt

Metallothinein-3 (MT3), also named neuronal growth inhibitory factor (GIF), is attractive by its distinct neuronal growth inhibitory activity, which is not shared by other MT isoforms. The polypeptide chain of GIF is folded into two individual domains, which are connected by a highly conserved linker, KKS. In order to figure out the significance of the conserved segment, we constructed several mutants of human...

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PMID: 19306065
DOI: 10.1007/s10534-009-9228-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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