Article
The role of Thr5 in human neuron growth inhibitory factor.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Jun 2006
Cai Bin, Zheng Qi, Teng Xin-Chen, Chen Dong, Wang Yang, Wang Ke-Qiang, Zhou Guo-Ming, Xie Yi, Zhang Ming-Jie, Sun Hong-Zhe, Huang Zhong-Xian
Abstract excerpt
GIF, a member of the metallothionein (MT) family (assigned as MT3), is a neuron growth inhibitory factor that inhibits neuron outgrowth in Alzheimer's disease. The conserved Thr5 is one of the main differences between GIF and other members in the MT family. However, natural sheep GIF has an unusual Ala5, casting doubt on the role of common Thr5. We constructed a series of human GIF mutants at site 5, and...
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