Article
Mutation at Glu23 eliminates the neuron growth inhibitory activity of human metallothionein-3.
Biochemical and biophysical research communications - 20 Oct 2006
Ding Zhi-Chun, Teng Xin-Chen, Cai Bin, Wang Hui, Zheng Qi, Wang Yang, Zhou Guo-Ming, Zhang Ming-Jie, Wu Hou-Ming, Sun Hong-Zhe, Huang Zhong-Xian
Abstract excerpt
Human metallothionein-3 (hMT3), first isolated and identified as a neuronal growth inhibitory factor (GIF), is a metalloprotein expressed predominantly in brain. However, until now, the exact mechanism of the bioactivity of hMT3 is still unknown. In order to study the influence of acid-base catalysis on S-nitrosylation of hMT3, we constructed the E23K mutant of hMT3. During the course of bioassay, we found out...
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