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Article

The effect of the EAAEAE insert on the property of human metallothionein-3.

Protein engineering - 1 Dec 2003

Zheng Qi, Yang Wan-Ming, Yu Wen-Hao, Cai Bin, Teng Xin-Chen, Xie Yi, Sun Hong-Zhe, Zhang Ming-Jie, Huang Zhong-Xian

Abstract excerpt

MT3 shows apparently different properties and function from MT1 even though they have 70% sequence homology. Possibly the two inserts, Thr5 and a negatively charged hexapeptide at position-55 in MT3, play important roles. A series of MT3 variants around the EAAEAE hexapeptide have been prepared by site-directed mutagenesis and their properties and reactivity towards pH, EDTA and DTNB have been studied. Our...

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Source

Identifiers

PMID: 14983064
DOI: 10.1093/protein/gzg127

Genes

DTNB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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