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Article

Effect of alpha-domain substitution on the structure, property and function of human neuronal growth inhibitory factor.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Nov 2007

Ding Zhi-Chun, Zheng Qi, Cai Bin, Yu Wen-Hao, Teng Xin-Chen, Wang Yang, Zhou Guo-Ming, Wu Hou-Ming, Sun Hong-Zhe, Zhang Ming-Jie, Huang Zhong-Xian

Abstract excerpt

Human metallothionein-3 (hMT3), also named human neuronal growth inhibitory factor (hGIF), is attractive due to its distinct neuronal growth inhibitory activity, which is not shown by other human MT isoforms. It has been reported that the neuronal growth inhibitory activity arises from the N-terminal beta-domain rather than its C-terminal alpha-domain. However, previous bioassay results have shown that the single...

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PMID: 17712581
DOI: 10.1007/s00775-007-0287-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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