Article
Incorporation of a glycine within the conserved TCPCP motif of human neuronal growth inhibitory factor significantly reduces its bioactivity.
Biochemical and biophysical research communications - 8 Aug 2008
Ding Zhi-Chun, Chen Dong, Ni Feng-Yun, Zheng Qi, Cai Bin, Yao Wen-Hua, Wang Yang, Zhou Guo-Ming, Huang Zhong-Xian
Abstract excerpt
It has been reported that the (6)CPCP(9) motif near the N-terminus is pivotal to the inhibitory activity of human neuronal growth inhibitory factor (hGIF). In order to better understand the biological significance of this region on the structure, property and function of hGIF, we introduced a highly flexible residue, Gly, either in front of the (6)CPCP(9) motif (the IG6 mutant, TGCPCP) or in the middle of it (the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.