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Article

The alpha helix of the intermediate region in hGBP-1 acts as a coupler for enhanced GMP formation.

Biochimica et biophysica acta. Proteins and proteomics - 1 May 2020

Rajan Sudeepa, Sau Apurba Kumar

Abstract excerpt

The interferon-gamma inducible large GTPase human guanylate binding protein-1 (hGBP-1) plays a key role in anti-pathogenic and anti-proliferative functions. This protein hydrolyzes GTP to both GDP and GMP (predominant product) through sequential phosphate cleavages, which makes it functionally distinct from other GTPases. Previous study on truncated variants of hGBP-1 suggested that the α-helix present in the...

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Identifiers

PMID: 31954926
DOI: 10.1016/j.bbapap.2020.140364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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