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Article

The role of zinc finger linkers in zinc finger protein binding to DNA.

Journal of computer-aided molecular design - 1 Sept 2021

Hamed Mazen Y, Siam Reema, Zaid Roza

Abstract excerpt

Zinc finger proteins (ZFP) play important roles in cellular processes. The DNA binding region of ZFP consists of 3 zinc finger DNA binding domains connected by amino acid linkers, the sequence TGQKP connects ZF1 and ZF2, and TGEKP connects ZF2 with ZF3. Linkers act to tune the zinc finger protein in the right position to bind its DNA target, the type of amino acid residues and length of linkers reflect on...

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PMID: 34350488
DOI: 10.1007/s10822-021-00413-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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