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Article

Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2012

Bainbridge Shannon A, Minhas Abhijeet, Whiteley Kathie J, Qu Dawei, Sled John G, Kingdom John C P, Adamson S Lee

Abstract excerpt

Preeclampsia is a life-threatening disorder characterized by maternal gestational hypertension and proteinuria that results from placental dysfunction. Placental abnormalities include abnormal syncytiotrophoblast and a 50% reduction in placental expression of the transcription factor Gcm1. In mice, homozygous deletion of Gcm1 prevents syncytiotrophoblast differentiation and is embryonic lethal. We used...

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Source

Identifiers

PMID: 22275534
DOI: 10.1161/HYPERTENSIONAHA.111.183939

Genes

GCM1

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Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.PMID 22275534Read ↗

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