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Article

Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men.

Obesity (Silver Spring, Md.) - 1 Sept 2009

Moreno-Navarrete José M, Botas Patricia, Valdés Sergio, Ortega Francisco J, Delgado Elías, Vázquez-Martín Alejandro, Bassols Judit, Pardo Gerard, Ricart Wifredo, Menéndez Javier A, Fernández-Real José M

Abstract excerpt

The Val1483Ile polymorphism in the human fatty acid synthase (FASN) gene is located within the interdomain region of the FASN close to the two dynamic active centers of the FASN enzyme and putatively affects FASN action. We aimed to evaluate the association of this polymorphism with obesity phenotypes, insulin sensitivity, and adipose tissue FASN activity in adult white subjects. The polymorphism was evaluated in...

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Source

Identifiers

PMID: 19300427
DOI: 10.1038/oby.2009.65

Genes

FASN
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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