Article
A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians.
Diabetes - 1 Jul 2004
Kovacs Peter, Harper Inge, Hanson Robert L, Infante Aniello M, Bogardus Clifton, Tataranni P Antonio, Baier Leslie J
Abstract excerpt
Inhibition of fatty acid synthase (FAS) induces a rapid decline in fat stores in mice, suggesting a role for this enzyme in energy homeostasis. The human FAS gene (FAS) maps to chromosome 17q25, a region previously shown to have suggestive linkage to adiposity in a genome-wide linkage scan for genetic determinants of obesity in Pima Indians. To investigate the potential role of FAS in the pathophysiology of human...
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