Article
The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.
Disease markers - 1 Jan 2005
Fanelli Marzia, Filippi Emanuela, Sentinelli Federica, Romeo Stefano, Fallarino Mara, Buzzetti Raffaella, Leonetti Frida, Baroni Marco Giorgio
Abstract excerpt
Among the putative candidate genes for insulin resistance, the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator of PPARgamma and alpha, regulating a wide range of processes involved in energy production and utilization, such as thermogenesis, liver gluconeogenesis, glucose uptake in muscle. In population studies a Gly482Ser substitution in...
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