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Article

Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression.

Obesity (Silver Spring, Md.) - 1 Jun 2010

Schleinitz Dorit, Klöting Nora, Körner Antje, Berndt Janin, Reichenbächer Marlene, Tönjes Anke, Ruschke Karen, Böttcher Yvonne, Dietrich Kerstin, Enigk Beate, Filz Matthias, Schön Michael R, Jenkner Jost, Kiess Wieland, Stumvoll Michael, Blüher Matthias, Kovacs Peter

Abstract excerpt

Inhibition of fatty acid synthase (FASN) induces a rapid decline in fat stores in mice, suggesting a role for this enzyme in energy homeostasis. To investigate the potential role of FASN in the pathophysiology of human obesity, the FASN gene was sequenced in 48 German whites. Thirty-five single-n...

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Source

Identifiers

PMID: 19876008
DOI: 10.1038/oby.2009.392

Genes

FASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19876008-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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