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Article

Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects.

Pharmacogenetics - 1 Jul 2003

Nielsen Eva-Maria D, Hansen Lars, Echwald Søren M, Drivsholm Thomas, Borch-Johnsen Knut, Ekstrøm Claus T, Hansen Torben, Pedersen Oluf

Abstract excerpt

The aim of the study was to investigate whether genetic variation in the peroxisome proliferator-activated receptor-alpha (PPARalpha) is associated with type 2 diabetes and altered lipid or carbohydrate metabolism in glucose tolerant subjects. Mutation analyses of PPARalpha were performed in 56 type 2 diabetic patients. Six variants were identified: IVS3 + 76T>C, IVS3-19C>T, IVS4 + 35C>T, Leu162Val, Arg178Gly and...

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Identifiers

PMID: 12835617
DOI: 10.1097/01.fpc.0000054105.48725.5c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects.PMID 12835617Read ↗

Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men.Semantic proximity Read ↗

Association Between the PPARA L162V Polymorphism and Plasma Lipid LevelsSemantic proximity Read ↗

A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPAR α) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitusSemantic proximity Read ↗

Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome.Semantic proximity Read ↗

The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition.Semantic proximity Read ↗

The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene is not associated with postprandial responses to glucose or fat tolerance tests in young healthy subjects: the European Atherosclerosis Research Study II.Semantic proximity Read ↗

Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease.Semantic proximity Read ↗

The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.Semantic proximity Read ↗

Impact of PPAR-Alpha Polymorphisms—The Case of Metabolic Disorders and AtherosclerosisSemantic proximity Read ↗

Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus.Semantic proximity Read ↗

Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men.Semantic proximity Read ↗

PPARα-L162V polymorphism is not associated with schizophrenia risk in a Croatian population.Semantic proximity Read ↗

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