Article
Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans.
Thrombosis and haemostasis - 26 Jan 2017
Lallukka Susanna, Luukkonen Panu K, Zhou You, Isokuortti Elina, Leivonen Marja, Juuti Anne, Hakkarainen Antti, Orho-Melander Marju, Lundbom Nina, Olkkonen Vesa M, Lassila Riitta, Yki-Järvinen Hannele
Abstract excerpt
Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT), activities of...
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