TCR<i>ζ</i>chain expression in T cells from patients with CML

Abstract excerpt

Chronic myeloid leukemia (CML) is a clonal disorder of the stem cells which has impaired cell-mediated immune response. Such immune dysfunction may be due to reduced expression of the T-cell receptor (TCR) zeta chain, which is an important component in TCR-mediated signal transduction. In this study, the TCR zeta expression level was detected using a real-time polymerase chain reaction with SYBR Green I technique...

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