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TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus

1 Jul 1998

Abstract excerpt

To address the molecular mechanism underlying the functional defects of peripheral T cells in systemic lupus erythematosus (SLE), we focused on early signaling events. We demonstrated that protein expression of the TCR zeta chain was significantly decreased in peripheral T cells from patients with SLE compared to normal controls and patients with systemic sclerosis (SSc). Among those patients showing decreased...

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PMID: 9701029
DOI: 10.1093/intimm/10.7.911

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