Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients.

Springer seminars in immunopathology - 1 Oct 2006

Tsuzaka Kensei, Nozaki Kyoko, Kumazawa Chika, Shiraishi Kiyono, Setoyama Yumiko, Yoshimoto Keiko, Abe Tohru, Takeuchi Tsutomus

Abstract excerpt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology. Tyrosine phosphorylation and protein expression of the T-cell receptor zeta chain (zeta) have been reported to be significantly decreased in SLE T cells. In addition, zeta mRNA with alternatively spliced 3' untranslated region (zetamRNA/as-3'UTR) is detected predominantly in SLE T cells, and aberrant zeta mRNA accompanied by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Down-Regulation

Share to Lupus Erythematosus, Systemic

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Source

Identifiers

PMID: 16953440
DOI: 10.1007/s00281-006-0035-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients.PMID 16953440Read ↗

DNA microarray gene expression profile of T cells with the splice variants of TCRzeta mRNA observed in systemic lupus erythematosus.Semantic proximity Read ↗

Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Mutations in T cell receptor zeta chain mRNA of peripheral T cells from systemic lupus erythematosus patients.Semantic proximity Read ↗

Alterations in the expression pattern of TCR zeta chain in T cells from patients with hematological diseases.Semantic proximity Read ↗

Decreased Stability and Translation of T Cell Receptor ζ mRNA with an Alternatively Spliced 3′-Untranslated Region Contribute to ζ Chain Down-regulation in Patients with Systemic Lupus ErythematosusSemantic proximity Read ↗

TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosusSemantic proximity Read ↗

Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.Semantic proximity Read ↗

Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.Semantic proximity Read ↗

Deficiency of CD3gamma, delta, epsilon, and zeta expression in T cells from AML patientsSemantic proximity Read ↗

CD3 ζ defects in systemic lupus erythematosus.Semantic proximity Read ↗

CD247 variants and single-nucleotide polymorphisms observed in systemic lupus erythematosus patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.