Article
Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation.
Blood - 15 Oct 2003
Rezvani Katayoun, Grube Matthias, Brenchley Jason M, Sconocchia Giuseppe, Fujiwara Hiroshi, Price David A, Gostick Emma, Yamada Ko, Melenhorst Jan, Childs Richard, Hensel Nancy, Douek Daniel C, Barrett A John
Abstract excerpt
Antigens implicated in the graft-versus-leukemia (GVL) effect in chronic myeloid leukemia (CML) include WT1, PR1, and BCR-ABL. To detect very low frequencies of these antigen-specific CD8+ T cells, we used quantitative polymerase chain reaction (qPCR) to measure interferon-gamma (IFN-gamma) mRNA...
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