Article
Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.
The Journal of biological chemistry - 21 Jun 2013
Kong Guangyao, Du Juan, Liu Yangang, Meline Benjamin, Chang Yuan-I, Ranheim Erik A, Wang Jinyong, Zhang Jing
Abstract excerpt
Acute T-cell lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematopoietic malignancy affecting both children and adults. Previous studies of T-ALL mouse models induced by different genetic mutations have provided highly diverse results on the issues of T-cell leukemia/lymphoma-initiating cells (T-LICs) and potential mechanisms contributing to T-LIC transformation. Here, we show that oncogenic Kras (Kras...
Topics
- Adult
- Animals
- Bone Marrow Transplantation
- CD8-Positive T-Lymphocytes
- Cell Transformation, Neoplastic
- Flow Cytometry
- Humans
- Kaplan-Meier Estimate
- Mice
- Mice, Inbred BALB C
- Mutation
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Preleukemia