Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary Conservation of Vertebrate Blood–Brain Barrier Chemoprotective Mechanisms in<i>Drosophila</i>

18 Mar 2009

Abstract excerpt

Pharmacologic remedy of many brain diseases is difficult because of the powerful drug exclusion properties of the blood-brain barrier (BBB). Chemical isolation of the vertebrate brain is achieved through the highly integrated, anatomically compact and functionally overlapping chemical isolation processes of the BBB. These include functions that need to be coordinated between tight diffusion junctions and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barrier Structure and Function Studies
Share to Drug Transport and Resistance Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19295159
DOI: 10.1523/jneurosci.5564-08.2009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary Conservation of Vertebrate Blood–Brain Barrier Chemoprotective Mechanisms in<i>Drosophila</i>PMID 19295159Read ↗

Evolutionarily Conserved Roles For Blood-Brain Barrier Xenobiotic Transporters In Endogenous Steroid Partitioning And BehaviorSemantic proximity Read ↗

The canine blood-brain barrier in health and disease: focus on brain protectionSemantic proximity Read ↗

Characterization and tissue localization of zebrafish homologs of the human <i>ABCB1</i> multidrug transporterSemantic proximity Read ↗

The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discoverySemantic proximity Read ↗

Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug DiscoverySemantic proximity Read ↗

An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossingSemantic proximity Read ↗

Isolation and characterization of Drosophila multidrug resistance gene homologs.Semantic proximity Read ↗

Determinants of drug entry into the developing brainSemantic proximity Read ↗

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin AnaloguesSemantic proximity Read ↗

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval ZebrafishSemantic proximity Read ↗

Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.