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Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug Discovery

24 Feb 2022

Abstract excerpt

BACKGROUND AND OBJECTIVE: Compound X is a drug candidate for the treatment of neurodegenerative diseases. Its brain distribution was evaluated as part of the lead identification and optimization activities undertaken in early drug discovery. METHODS: The brain distribution of compound X was studied in genetic transporter knockout rodent models, in vivo models with a chemical inhibitor, and in vitro transporter...

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PMID: 35196975
DOI: 10.2174/1872312815666220222091032

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