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The canine blood-brain barrier in health and disease: focus on brain protection

10 Jan 2025

Abstract excerpt

This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the ABCB1/MDR1 gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key...

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PMID: 39791202
DOI: 10.1080/01652176.2025.2450041

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