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Article

Isolation and characterization of Drosophila multidrug resistance gene homologs.

Molecular and cellular biology - 1 Aug 1991

Wu C T, Budding M, Griffin M S, Croop J M

Abstract excerpt

Mammalian multidrug-resistant cell lines, selected for resistance to a single cytotoxic agent, display cross-resistance to a broad spectrum of structurally and functionally unrelated compounds. These cell lines overproduce a membrane protein, the P-glycoprotein, which is encoded by a member(s) of a multigene family, termed mdr or pgp. The amino acid sequence of the P-glycoprotein predicts an energy-dependent...

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Identifiers

PMID: 2072901
DOI: 10.1128/mcb.11.8.3940-3948.1991
PMCID: PMC361188

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