Isolation and characterization of Drosophila multidrug resistance gene homologs.

doi:10.1128/mcb.11.8.3940-3948.1991

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Article

Isolation and characterization of Drosophila multidrug resistance gene homologs.

Molecular and cellular biology - 1 Aug 1991

Wu C T, Budding M, Griffin M S, Croop J M

Abstract excerpt

Mammalian multidrug-resistant cell lines, selected for resistance to a single cytotoxic agent, display cross-resistance to a broad spectrum of structurally and functionally unrelated compounds. These cell lines overproduce a membrane protein, the P-glycoprotein, which is encoded by a member(s) of a multigene family, termed mdr or pgp. The amino acid sequence of the P-glycoprotein predicts an energy-dependent...

Topics

ATP Binding Cassette Transporter, Subfamily B
Amino Acid Sequence
Animals
Chromosome Mapping
Cloning, Molecular
Colchicine
DNA
Drosophila
Drosophila Proteins
Drug Resistance
Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insect Hormones

Molecular Sequence Data

Multidrug Resistance-Associated Proteins

Mutation

Nucleic Acid Hybridization

Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 2072901
DOI: 10.1128/mcb.11.8.3940-3948.1991
PMCID: PMC361188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2072901-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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