Article
Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women.
Digestive diseases and sciences - 1 Mar 2010
Lin Zhenwu, Poritz Lisa, Franke Andre, Li Tong-Yi, Ruether Andreas, Byrnes Kathryn A, Wang Yunhua, Gebhard Anthony W, MacNeill Colin, Thomas Neal J, Schreiber Stefan, Koltun Walter A
Abstract excerpt
PURPOSE: To replicate the association of IL23R R381Q (rs11209026) with inflammatory bowel disease (IBD), examine the effect of the two nonsynonymous variations, Q3H and L310P, on IBD, and to study gender distribution of these variants in IBD patients. RESULTS: IL23R R381Q was associated with Crohn's disease (CD) (P = 0.010), but not with ulcerative colitis (UC); L310P was associated with UC (P = 0.004), but not...
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