Article
Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review.
Journal of immunotoxicology - 1 May 2016
Abdollahi Elham, Tavasolian Fataneh, Momtazi-Borojeni Amir Abbas, Samadi Morteza, Rafatpanah Houshang
Abstract excerpt
Interleukin-23 (IL-23) is a regulator of cellular immune responses involved in controlling infection and autoimmune diseases. Strong evidence has shown that IL-23 plays a role in the maintenance of immune responses by influencing the proliferation and survival of IL-17-producing T-helper (TH)-17 cells. The critical role of the IL-23/TH17 axis in immune-mediated diseases has emerged from different studies. It has...
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