Article
Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.
The Journal of biological chemistry - 16 Aug 2013
Mehrotra Swarna, Sharma Bhumika, Joshi Sonali, Kroczynska Barbara, Majchrzak Beata, Stein Brady L, McMahon Brandon, Altman Jessica K, Licht Jonathan D, Baker Darren P, Eklund Elizabeth A, Wickrema Amittha, Verma Amit, Fish Eleanor N, Platanias Leonidas C
Abstract excerpt
The mechanisms of generation of the antineoplastic effects of interferons (IFNs) in malignant hematopoietic cells remain to be precisely defined. We examined the activation of type I IFN-dependent signaling pathways in malignant cells transformed by Jak2V617F, a critical pathogenic mutation in myeloproliferative neoplasms (MPNs). Our studies demonstrate that during engagement of the type I IFN receptor (IFNAR),...
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