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Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis

29 Jan 2009

Abstract excerpt

Merkel cell carcinoma (MCC), a skin tumour with neuroendocrine features, was recently found to be associated with a new type of human polyomavirus, called Merkel cell virus (MCV). We investigated the specificity of this association as well as a causal role of MCV in oncogenesis. DNA and RNA from ten cases of MCC were analysed using PCR and RT-PCR. DNA from 1241 specimens of a wide range of human tumours was also...

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PMID: 19291712
DOI: 10.1002/path.2532

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