Article

Merkel cell polyomavirus in Merkel cell carcinoma: Integration sites and involvement of the KMT2D tumor suppressor gene

2020-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either Merkel cell polyomavirus (MCV) or UV-linked mutations. MCV is found integrated into MCC tumor genomes, accompanied by truncation mutations that render the MCV large T antigen replication incompetent. We used the open access HPV Detector/ Cancervirus Detector tool to determine the MCV integration sites in whole...

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Literature Corpus work: 584631a0-95e0-504b-9a60-739c923bca13
DOI: 10.1101/2020.08.03.234799

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