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Article

Whole genome sequencing elucidates etiological differences in MCPyV-negative Merkel cell carcinoma.

Pathology, research and practice - 1 Nov 2024

Stephan Carla, Al Assaad Majd, Levine Max F, Deshpande Aditya, Sigouros Michael, Manohar Jyothi, Sboner Andrea, Elemento Olivier, Pavlick Anna C, Mosquera Juan Miguel

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine neoplasm of the skin. Immunosuppression, ultraviolet radiation and the integration of Merkel cell polyomavirus (MCPyV) have all been shown to be involved in the pathogenesis of this malignancy. We performed whole genome sequencing on two MCPyV-negative cases of MCC that demonstrated very different clinical presentations and outcomes, and mutational...

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PMID: 39427588
DOI: 10.1016/j.prp.2024.155668

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