Article

E41K Mutation Activates Bruton’s Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate dependent Invisible Dimer

2024-01-23

Abstract excerpt

Bruton’s tyrosine kinase (BTK) regulates diverse cellular signaling of the innate and adaptive immune system in response to microbial pathogens. Downregulation or constitutive activation of BTK is reported in patients with autoimmune diseases or various B-cell leukemias. BTK is a multidomain protein tyrosine kinase that adopts an Src-like autoinhibited conformation maintained by the interaction between the kinase...

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Literature Corpus work: 783f8938-c957-5ff3-96ff-f175b91e7a93
DOI: 10.1101/2024.01.22.576617

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