Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diseases associated with the low copy number of the C4B gene encoding C4, the fourth component of complement.

Cytogenetic and genome research - 1 Jan 2008

Szilágyi A, Fust G

Abstract excerpt

In this review article, earlier and recent work of the research group on the copy number polymorphism of the C4B gene are summarized. In a study performed in 1991 a sharp decrease was found among healthy elderly (>60 years old) people as compared to healthy young (<45 years old) people in the frequency of the individuals with a low copy number of the C4B gene (one of the two genes (C4A and C4B) encoding the C4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement C4
Share to Disease
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 19287146
DOI: 10.1159/000184699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diseases associated with the low copy number of the C4B gene encoding C4, the fourth component of complement.PMID 19287146Read ↗

Investigation of complement component C4 copy number variation in human longevity.Semantic proximity Read ↗

Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction.Semantic proximity Read ↗

Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality.Semantic proximity Read ↗

Real-time PCR quantification of human complement C4A and C4B genesSemantic proximity Read ↗

An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.Semantic proximity Read ↗

Genetic determinants of variation in the plasma levels of the C4b-binding protein (C4BP) in Spanish families.Semantic proximity Read ↗

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Polymorphism of C3 complement in association with myocardial infarction in a sample of central Tunisia.Semantic proximity Read ↗

[Analysis of the genetic variability of complement component C4 by real-time PCR].Semantic proximity Read ↗

Molecular analysis of complement component C4 gene copy number.Semantic proximity Read ↗

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.Semantic proximity Read ↗

A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.