Real-time PCR quantification of human complement C4A and C4B genes

doi:10.1186/1471-2156-7-1

Article

Real-time PCR quantification of human complement C4A and C4B genes

10 Jan 2006

Abstract excerpt

BACKGROUND: The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome. Although these genes differ only in 5 nucleotides, the encoded C4A and C4B proteins are functionally different. Based on phenotypic determination, unbalanced production of C4A and C4B is associated with several diseases, such as systemic lupus...

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