Article
Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction.
International immunology - 1 Jan 2008
Blaskó Bernadett, Kolka Ragnhildur, Thorbjornsdottir Perla, Sigurdarson Sigurdur Thór, Sigurdsson Gardar, Rónai Zsolt, Sasvári-Székely Mária, Bödvarsson Sigurdur, Thorgeirsson Gudmundur, Prohászka Zoltán, Kovács Margit, Füst George, Arason Gudmundur Jóhann
Abstract excerpt
BACKGROUND AND OBJECTIVES: Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy number of the C4B gene that encodes the fourth component of complement) is strongly associated with morbidity and mortality of cardiovascular diseases (CVD). The +252 G allele of the lymphotoxin-alpha (LTA) gene encoded close to the...
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