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Article

An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.

Annals of the New York Academy of Sciences - 1 Dec 2003

Arason Gudmundur Jóhann, Bödvarsson Sigurdur, Sigurdarson Sigurudr Thor, Sigurdsson Gardar, Thorgeirsson Gudmundur, Gudmundsson Sveinn, Kramer Judit, Füst Georg

Abstract excerpt

We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observ...

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PMID: 15033778
DOI: 10.1196/annals.1299.091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15033778-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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