Article
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality.
Clinical and experimental immunology - 1 Jul 2007
Arason G J, Kramer J, Blaskó B, Kolka R, Thorbjornsdottir P, Einarsdóttir K, Sigfúsdóttir A, Sigurdarson S T, Sigurdsson G, Rónai Z, Prohászka Z, Sasvári-Székely M, Bödvarsson S, Thorgeirsson G, Füst G
Abstract excerpt
We have demonstrated previously that carriers of a genotype called C4B*Q0 (silent allele of the C4B gene) have a substantially increased risk to suffer from myocardial infarction or stroke, and are selected out from the healthy elderly population. Because smoking carries a major risk for cardiovascular disease (CVD), it seemed worthwhile to study if these two factors interact. Study 1 involved 74 patients with...
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