A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival.

doi:10.1007/BF00201547

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Article

A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4BQ0) in elderly subjects: C4BQ0 as a probable negative selection factor for survival.

Human genetics - 1 Apr 1991

Kramer J, Fülöp T, Rajczy K, Nguyen A T, Füst G

Abstract excerpt

The incidence of allotypes of the genes of the fourth component (C4) and factor B of the complement system was compared in 252 persons under 45 years of age ("young" group) with 482 people between 61 and 90 years of age ("old" group). One hundred people older than 90 years of age (nonagenarians)...

Topics

Adult
Aged
Aged, 80 and over
Aging
Alleles
Chi-Square Distribution
Complement C4b
Female
Gene Frequency
Humans
Longevity
Male
Middle Aged
Selection, Genetic

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