Article
Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma.
Endocrine-related cancer - 1 Jun 2009
Akulevich Natallia M, Saenko Vladimir A, Rogounovitch Tatiana I, Drozd Valentina M, Lushnikov Eugeny F, Ivanov Victor K, Mitsutake Norisato, Kominami Ryo, Yamashita Shunichi
Abstract excerpt
Papillary thyroid carcinoma (PTC) etiologically occurs as a radiation-induced or sporadic malignancy. Genetic factors contributing to the susceptibility to either form remain unknown. In this retrospective case-control study, we evaluated possible associations between single-nucleotide polymorphisms (SNPs) in the candidate DNA damage response genes (ATM, XRCC1, TP53, XRCC3, MTF1) and risk of radiation-induced and...
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