Article
Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Jun 2012
Xu Li, Morari Elaine Cristina, Wei Qingyi, Sturgis Erich M, Ward Laura S
Abstract excerpt
CONTEXT: ATM is critical in response to ionizing radiation-induced DNA damage. OBJECTIVE: Variations in ATM are hypothesized to affect individual susceptibility to thyroid cancer. Our objective was to evaluate the association between ATM polymorphisms and thyroid cancer risk. DESIGN, PARTICIPANTS, AND METHODS: Six ATM single nucleotide polymorphisms (SNP) were genotyped in two independent case-control series...
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