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Article

Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma.

Genes, chromosomes & cancer - 1 Jun 2014

Wójcicka Anna, Czetwertyńska Małgorzata, Świerniak Michał, Długosińska Joanna, Maciąg Monika, Czajka Agnieszka, Dymecka Kinga, Kubiak Anna, Kot Adam, Płoski Rafał, de la Chapelle Albert, Jażdżewski Krystian

Abstract excerpt

The risk of developing papillary thyroid carcinoma (PTC), the most frequent form of thyroid malignancy, is elevated up to 8.6-fold in first-degree relatives of PTC patients. The familial risk could be explained by high-penetrance mutations in yet unidentified genes, or polygenic action of low-penetrance alleles. Since the DNA-damaging exposure to ionizing radiation is a known risk factor for thyroid cancer,...

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Identifiers

PMID: 24599715
DOI: 10.1002/gcc.22162
PMCID: PMC4058861

Genes

BRCA1
ATM
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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