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Mismatch Repair Protein Deficiency Compromises Cisplatin-induced Apoptotic Signaling

14 Mar 2009

Abstract excerpt

Mismatch repair (MMR) proteins participate in cytotoxicity induced by certain DNA damage-inducing agents, including cisplatin (cis-diamminedichloroplatinum(II), CDDP), a cancer chemotherapeutic drug utilized clinically to treat a variety of malignancies. MMR proteins have been demonstrated to bind to CDDP-DNA adducts and initiate MMR protein-dependent cell death in cells treated with CDDP; however, the molecular...

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PMID: 19286655
DOI: 10.1074/jbc.m809303200

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