Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.

Cancer research - 15 Dec 2000

Bergeron J, Benlimame N, Zeng-Rong N, Xiao D, Scrivens P J, Koromilas A E, Alaoui-Jamali M A

Abstract excerpt

The double-stranded RNA-dependent protein kinase PKR plays a central role in IFN-mediated antiviral response. The ability of PKR mutants to transform rodent fibroblasts led to the hypothesis that PKR acts as a tumor suppressor. Recent studies have identified an expanding network of PKR signaling partners, including signal transducers and activators of transcription 1 (STAT1), p53, and IkappaB-kinase. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Alkylating
Share to Cisplatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Adducts

Share to Doxorubicin

Share to eIF-2 Kinase

Share to Melphalan

Share to Retroviridae

Share to RNA, Double-Stranded

Source

Identifiers

PMID: 11156368

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.PMID 11156368Read ↗

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.Semantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

<i>PKR</i> , a <i>p53</i> target gene, plays a crucial role in the tumor-suppressor function of <i>p53</i>Semantic proximity Read ↗

Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein KinaseSemantic proximity Read ↗

Comparative gene expression in cells competent in or lacking DNA-PKcs kinase activity following etoposide exposure reveal differences in gene expression associated with histone modifications, inflammation, cell cycle regulation, Wnt signaling, and differentiationSemantic proximity Read ↗

Beyond DNA Repair: DNA-PK Function in CancerSemantic proximity Read ↗

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.Semantic proximity Read ↗

DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer.Semantic proximity Read ↗

Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase RSemantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

p53-deficient cells display increased sensitivity to anthracyclines after loss of the catalytic subunit of the DNA-dependent protein kinase.Semantic proximity Read ↗

Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.