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Mitomycin–DNA Adducts Induce p53-Dependent and p53-Independent Cell Death Pathways

25 May 2007

Abstract excerpt

10-Decarbamoyl-mitomycin C (DMC), a mitomycin C (MC) derivative, generates an array of DNA monoadducts and interstrand cross-links stereoisomeric to those that are generated by MC. DMC was previously shown in our laboratory to exceed the cytotoxicity of MC in a human leukemia cell line that lacks a functional p53 pathway (K562). However, the molecular signal transduction pathway activated by DMCDNA adducts has...

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PMID: 17530733
DOI: 10.1021/cb700060t

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